Temp Resarch Associate I, NGS Sample Preparation

Regeneron Pharmaceuticals
Jul 17, 2017
Jul 21, 2017
Employer Type
Direct Employer
Employment Type
Full Time
The Regeneron Genetics Center is a wholly-owned subsidiary of the Company organized to collaborate with health systems and research groups to elucidate, on a large scale, genetic factors that cause or influence a range of human diseases. Building upon Regeneron's strengths in mouse genetics and genetics-driven drug discovery and development, the Center will specialize in ultra-high-throughput exome sequencing and computational biology; discovery of genotype-phenotype associations through linkage to well-annotated de-identified patient electronic medical records; and validation of discoveries using Regeneron?s VelociGene? technology. Our interests encompass a breadth of different areas such as Mendelian and family frameworks, large-scale population genetics (both common and rare variants), and gene-gene interactions. Program goals include target discovery, indication discovery, and patient-disease stratification. Objectives include advancing basic science around the world through public sharing of discoveries, providing clinically-valuable insights to physicians and patients of collaborating health-care systems, and identifying novel targets for drug development.


We are looking for a Research Associate - Sample and Library Preparation, who will report to the Manager - Sequencing and Lab Operations. This Research Associate will be responsible for preparing human DNA samples for exome capture on our custom automation platforms.


- Receiving DNA samples from collaborators, logging samples into our database, and storing in our biobank

- Operating our custom automation platforms to create DNA libraries for exome capture and genotyping

- Logging sample information into our library information management system (LIMS)

- Performing quality control (QC) assays using gel electrophoresis, UV spectrometry, fluorometry, and quantitative real-time PCR

- Monitoring QC data and identifying samples not meeting our established standards for passing QC values

- Troubleshooting procedures related to sequencing library construction

- Collaborating with our automation core team to test new methods related to sequencing library construction

- Validating and implementing new technologies introduced at the Center


This position requires a minimum of a Bachelor?s Degree and some experience working in a molecular biology lab.

Preferred experience would include:

- Familiarity with next-generation sequencing approaches and technology

- Using a library information management system (LIMS)

- Various molecular biology techniques such as PCR, gel electrophoresis, and quantitative real-time PCR.

- Operation of an automation platform (e.g. a liquid handling robot)

- Familiarity with standard DNA laboratory QC instruments (e.g. UV spectrometer, microplate reader, Agilent Bioanalyzer, QIAxcel, ABI7900, LightCycler 480).

Would prefer a bachelors degree and some experience working in a molecular biology lab, preferably one that handled DNA.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron Genetics Center?s unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron or the Regeneron Genetics Center about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron or the Regeneron Genetics Center via-email, the internet or in any form and/or method will be deemed the sole property of the Regeneron Genetics Center, unless such search firms/employment agencies were engaged by Regeneron or the Regeneron Genetics Center for this position and a valid agreement with either Regeneron or the Regeneron Genetics Center is in place. In the event a candidate who was submitted outside of the Regeneron or Regeneron Genetics Center agency engagement process is hired, no fee or payment of any kind will be paid.

RGC is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.